H2N2V1, Main, Exploration, bibRecord, 002B42

The production of live attenuated influenza A strains by recombination with A/Okuda/57 (H2N2)

Identifieur interne : 002B42 ( Main/Exploration ); précédent : 002B41; suivant : 002B43

The production of live attenuated influenza A strains by recombination with A/Okuda/57 (H2N2)

Auteurs : D. Mccahon ; A. S. Beare ; V. Stealey

Source :

Postgraduate Medical Journal [ 0032-5473 ] ; 1976-06.

RBID : ISTEX:37845569B741C120EADFFD947319B10A2D8D55B3

Descripteurs français

KwdFr :
- Humains, Muqueuse nasale (microbiologie), Orthomyxoviridae (immunologie), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux (effets indésirables), Vaccins atténués, Virus de la grippe A (immunologie).
MESH :
- effets indésirables : Vaccins antigrippaux.
- immunologie : Orthomyxoviridae, Virus de la grippe A.
- microbiologie : Muqueuse nasale.
- Humains, Recombinaison génétique, Sous-type H2N2 du virus de la grippe A, Vaccins atténués.

English descriptors

KwdEn :
- Humans, Influenza A Virus, H2N2 Subtype, Influenza A virus (immunology), Influenza Vaccines (adverse effects), Nasal Mucosa (microbiology), Orthomyxoviridae (immunology), Recombination, Genetic, Vaccines, Attenuated.
MESH :
- chemical , adverse effects : Influenza Vaccines.
- immunology : Influenza A virus, Orthomyxoviridae.
- microbiology : Nasal Mucosa.
Teeft :
- Antibody response, Attenuated, Attenuation, Beare, Biological standardization, Candidate vaccine strain, Clinical reactions, Clinical score, Control cultures, Embryonated eggs, Fowl erythrocytes, Genetic stability, Good growth capacity, Good immunogenicity, High frequency, Human passage, Human population, Humans, Influenza, Influenza A Virus, H2N2 Subtype, Influenza virus, Influenza virus vaccines, Initial serum, Japanese strain, Limit dilution, Mccahon, Nasal washings, Parent virus, Parent viruses, Passage history, Potential vaccine strains, Preliminary testing, Recombinant, Recombinant viruses, Recombinants viruses, Recombination, Recombination system, Recombination, Genetic, Seronegative, Seronegative volunteers, Several trials, Severe reaction, Total number, Unpublished results, Vaccine, Vaccine strain, Vaccine strains, Vaccines, Attenuated, Virulent, Virulent parent virus, Virus, Virus excretion, Volunteer, Volunteer trials.

Abstract

A new recombination system for the production of live attenuated influenza-A vaccine strains is described. The attenuated parent is the Japanese strain A/Okuda/57 (H2N2) which has a known passage history and a good record of human safety. This virus has been recombined with two recent field isolates, A/England/42/72 and A/Finland/4/74, and in each case several recombinants were isolated and tested in volunteers. These recombinants differed in their degree of attenuation, but on each occasion it was possible to choose one that was suitably attenuated for a candidate vaccine strain. The genetic stability of such a recombinant produced with the A/England/42/72 strain was demonstrated by subjecting it to three successive human passages. A single intra-nasal dose of the A/Finland/4/74 recombinant vaccine gave a seroconversion rate of 75%. This recombination system offers considerable advantages for the production of live influenza virus vaccines.

Url:

DOI: 10.1136/pgmj.52.608.389

Affiliations:

Le document en format XML

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<term>Influenza Vaccines (adverse effects)</term>
<term>Nasal Mucosa (microbiology)</term>
<term>Orthomyxoviridae (immunology)</term>
<term>Recombination, Genetic</term>
<term>Vaccines, Attenuated</term>
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<term>Recombinaison génétique</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
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<term>Vaccins atténués</term>
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<front><div type="abstract" xml:lang="en">A new recombination system for the production of live attenuated influenza-A vaccine strains is described. The attenuated parent is the Japanese strain A/Okuda/57 (H2N2) which has a known passage history and a good record of human safety. This virus has been recombined with two recent field isolates, A/England/42/72 and A/Finland/4/74, and in each case several recombinants were isolated and tested in volunteers. These recombinants differed in their degree of attenuation, but on each occasion it was possible to choose one that was suitably attenuated for a candidate vaccine strain. The genetic stability of such a recombinant produced with the A/England/42/72 strain was demonstrated by subjecting it to three successive human passages. A single intra-nasal dose of the A/Finland/4/74 recombinant vaccine gave a seroconversion rate of 75%. This recombination system offers considerable advantages for the production of live influenza virus vaccines.</div>
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The production of live attenuated influenza A strains by recombination with A/Okuda/57 (H2N2)

The production of live attenuated influenza A strains by recombination with A/Okuda/57 (H2N2)

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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